The human body is temperamental, and all systems rely on each other to function properly.  For the male reproductive system, this is especially true, as it works directly in conjunction with several other organ processes to function at optimal capacity.

The production of sperm is a very complex process that relies on the functioning of various organ processes working together and working normally.  A problem with one of these processes or systems can have an impact on sperm production.

If you have a comorbid condition or chronic medical condition, you may experience low fertility or infertility, and CryoChoice may be here to assist you in preserving your sperm for your future family.  

Check out the types of diseases below.
Hormone Imbalance

Your hypothalamus and pituitary glands both produce hormones that trigger sperm production in the testes / testicles.  If these vital organs within your brain are not functioning properly, hormone production may be altered causing a hormone imbalance.  Hormone imbalances can lead to a low sperm count and low fertility.

Celiac Disease

Research has shown that celiac disease can cause low fertility and infertility in men; however, moving to a low gluten diet has been said to improve sperm count.

Inflammatory Bowel Disease / Gastrointestinal Disorders

The research on IBD is still very limited in its connection to low fertility and infertility; however, at this time, the research suggests that the medications used to treat IBD, the often poor diets of those afflicted, and the surgeries associated with IBD are the most common factors associated with low fertility and infertility in men with IBD and other gastrointestinal disorders. 

Sexually Transmitted Diseases & Infections

STD’s, such as HIV / AIDS, can cause low fertility and infertility. In addition, many STI’s, such as chlamydia, gonorrhea, etc., can cause low fertility and infertility, if remain untreated.


Recurring prostatitis or infection to the prostate gland is another potential cause of low fertility and infertility. 


 The various impacts of diabetes are very public, and the impacts do not exclude fertility in men.  It has been well documented that defective sperm DNA is one of the leading causes of infertility, pregnancy failure, and miscarriage.  It has been researched and documented that over half of sperm cells from diabetic men were fragmented, compared to those that do not have diabetes.  Also, there was a higher rate of deletions of DNA in the cells and a much lower volume of semen overall.

Thyroid Diseases

Hypothyroidism, Hyperthyroidism, Graves’ Disease, and Hashimoto’s Thyroiditis are all well-known thyroid disorders indicative of an over or underactive thyroid.  Any time the thyroid gland is not functioning normally, a hormone imbalance can occur, which in turn can cause a low sperm count and low fertility.

Autoimmune Disorders

An immune response is when the body’s immune system works against itself.  Men having an immune response to their own sperm is not uncommon, and some studies have shown that 10% of infertility cases in men are caused by an immune response to the sperm they produce.  Essentially, men with autoimmune disorders may have antisperm antibodies getting in the way of their own fertility.  

Heart Disease

At this time, heart disease itself is not linked to low fertility or infertility.  However, the risk factors and medications associated with heart diseases are problematic.  For example, smoking, obesity, chronic stress, unhealthy eating habits, etc., are all high-risk contributing factors to heart disease and are linked to low fertility. In addition, statins, which are commonly used to treat heart disease, are also associated with low fertility and infertility.


Chronic stress has been clinically proven to negatively impact sperm production and sperm maturation, which can lead to not only low fertility and infertility, but difficulty conceiving and maintaining a pregnancy.  Researchers have also proven that men who have suffered more than one stressful life event in a twelve-month period had a lower sperm motility and morphology compared to men who did not experience any stressful life events.


One common myth regarding lowered sperm count and depression is that it is only the depression medication that is tied to low fertility and infertility; however, studies in neuroendocrinology have found that depression in males has been linked to an overall decrease in semen volume and sperm density, even while not on medications.


Also, inherited disorders (genetic / chromosomal disorders) can cause low fertility or infertility, such as Klinefelter Syndrome, Kallmann’s Syndrome, Kartagener’s Syndrome, and Cystic Fibrosis.

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